Even if you delete an ill-considered tweet or status, nobody can guarantee that everyone has not already read it and that there is not eg. a screenshot of it.
Keep in mind your boss and family
If you are going to publish something that would not please neither your boss or wife and mother, think about it again. Do not attack anyone and refrain from comments you might regret.
Think about possible scenarios
Before you send out a controversial message, thoroughly consider what can be follow and what you actually want to achieve.
Do not mix work and play
If you want a place to safely express your private views and share private experiences, establish it on Facebook. And consistently make sure that your network of friends includes only people you really know. Still, avoid too controversial topics.
-kk-